Kilrean Upper is a townland located in the Barony of Boylagh, within the Civil Parish of Killybegs Lower and the Electoral Division of Ardara, County Donegal. Its Irish name is Cill Riáin Uachtarach.

It spans an area of 6,065,126 square metres, which equates to approximately 2.34 square miles or 1,498 acres.

Kilrean Upper shares its borders with the following townlands:

• Derries, Meenachallow, Meenawannia, and Tullynaglaggan to the east.

• Drumnacross, Kilrean Lower, and Tullyard to the west.

• Tullyhonwar to the south.

The area includes the subtownland of Kilrean.